![]() If you need one with large dust cup size, then choose the Pet Hair Eraser, it is also the best selling one if you like the Lift Off feature, then buy the Lift Off version if you want one with automatic power cord rewinding, then go for the Turbo Rewind version if you want more attachments, buy the Turbo Pro it seems that the Turbo Plus has the best user rating. Swivel Steering for easy maneuvering around furniture, other obstacles, corners, etc.īissell Pet Hair Eraser or Lift Off or Turbo or Turbo Plus or Turbo Pro or Turbo Rewind which is the best one to buy?.Cyclonic Hair Spooling System with Hands-Free Empty means you do not need to touch the debris when dumping the bin. Triple Action Brush Roll + Scatter-Free Technology powerfully pick up pet hair even if its embedded Swivel Steering makes cleaning around furniture and.SmartSeal Allergen System traps fine dust and allergens inside the vacuum and emit clean air.Provides suction on both sides of the brush roll for edge cleaning.(Tested per tangle free protocol BTP0251-A with hair length 6 – 8 inches. CleanView Swivel Rewind Pet Vacuum Cleaner 2256. Look for it on the back of the bottle or can, near the bottom. Tangle-Free Brush Roll eliminates hair wrap. On cleaning formulas the model number is actually called an item number. ![]() Tool(tools images from Bissell infomercial) CleanView Swivel Rewind Pet also comes with our powerful multi-cyclonic suction which keeps dirt and debris secure in the dirt tank and away from the filters and motor, so they last longer. Pet TurboEraser Tool or 3-in-1 Stair Toolģ-in-1 Stair Tool or Pet Hair Eraser Tool 47 OVERALL SCORE RANKED 10 of 11 Carpet Cleaning - 35 2.9 Ease of Use - 25 4.7 Handling - 20 5.5 Hard Surface - 10 3.8 Pet Hair - 10 9.9 RELATED: Best Upright Vacuums of 2023 Our Verdict Overall, we can't say that we would readily recommend the Bissell CleanView Swivel Pet upright vacuum. Bissell CleanView Swivel Upright Vacuum with Cord Rewind Automatic cord rewind with 8.2 m (27 ft.) power cord Eliminate pet odours with the active carbon. ![]()
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475 komatsu dozer vs d117/21/2023 ![]() ![]() ![]() Give it time, and I'm sure a market will develop, but we're not there yet.įrom the info i have Brian the D11T CD is around 115 ton (incl SS ripper) and the D11T with U blade and SS ripper is 104, some wear plating no doubt adds to that but i am talking factory weights as they are easier to keep track of. I'm sure they would sell better than the 575 did, but I'm not sure they would be a great seller in the grand scheme of things.yet. So until they upsize the trucks from 400 tons, I don't see a real need for this size of dozer. Spreading a 400 ton load 1 meter thick only takes 5 relatively easy passes. ![]() Also, a D11 doesn't really have much of an issue pushing 400 ton loads. That would make it the same weight as a 575, but leave it 150 ponies shy. With the D11 running right around 115 tons right now, I don't think a 10 ton jump would be that great of an idea if you only propose jumping the HP by 150. Gav, the specs for the 575 list an operating weight of 126 tons, so that would place the dozer you suggest squarely into the same size class as a 575.but with 150 fewer ponies under the hood. Anybody care to see a life sized version of the giant dozers from the movie Avatar? The Komatsu D-1675 I'm just an observer from outside (of the mining industry, etc.) I have learned things from reading and talking to the occasional person I cross paths with. Would a D12 even be worth having/operating? What would such a monster cost? $3 million? $4 million? I'm just asking. Is there many other places Besides West Virginia and Kentucky where these machines have been used? I know I talked to someone a few years back that said that there just wasn't much of a market for these big dozers - the places that could use them was basically places where dozing was the main way of moving material - thus places in WV and KY. I was told by a Komatsu salesman three years ago or so that the D-575A had been discontinued. ![]() I think it would be fair to say if Cat built a D12 it would sell very well and much better than the 575 has and for all the same reasons today the more expensive D11 outsells the D475 by 3 to 1, back up and support, simple as that. The other side of it too is as more autonomous trucks come on line i see them mandating short tipping on dumps with everything having to be pushed over the edge. With ultra class shovels and trucks now becoming the norm and tip heads not changing i see safety rules coming in where trucks will have to tip short of the edge and more dozer pushing being required, if you have ever seen the pile a 400 ton truck leaves in a block tipping or paddock dumping operation and the job a D11 has to knock it down you will know what i mean. Something that needs to be considered in the potential D12 vs D575 context is if Cat was to introduce a D12 would it be D575 size? Personally i think not and i think a D12 would be more in the 125 ton range and around 1000HP. Please use this before clicking "post"? You may be surprised with what you see! After 20+ years the technology is dated, but I wouldn't be surprised to see a new iteration of something beyond the D475 in 3-7 years and probably diesel-electric "hybrid" at that point. Dont' take this out of context as I was also informed that when they were working, there was nothing else remotely close when it came to material being moved in a shift. In West Virginia, I was told stories of major repairs taking sometimes weeks to resolve because of parts having to be fabricated in Japan and then shipped. As previously mentioned, they certainly weren't flawless by any stretch of the imagination from what I've heard. Does anyone here know the total production or current population of D575s? I'll ask PG, but he may not answer. I would also opine that the ratio of D575 to D475 was more like 50+ to one. They were not fast, but they pushed a hell of a big pile over the edge every time! Personally I wouldn't be surprised if the true reason for their discontinuation (although I can't find any sort of news or press release to confirm this), is simply lack of orders. Watching them at Princess Beverly more years ago than I can remember, they were staggered like combines in an Iowa cornfield and was a sight to see! Even when they would start to "carry" the overburden would still continue to increase. ![]() ![]() ![]() ![]() In medullated nerve fibre, the velocity of transmission is higher as an impulse has to jump from one node of Ranvier to the next. The velocity of transmission is higher in voluntary fibres (100 - 120 m/s in man) as compared to autonomic or involuntary nerves (10-20 m/s). When neurons undergo activation or firing (that is, sending out an electrical impulse), neural. In other words, neurons are centers of communication inside the nervous system. ![]() It is an electrically excitable cell that transfers information within the nervous system. It is higher in homeotherms than in poikilotherms. The neuron is the functional unit of the nervous system. Velocity: The rate of transmission of impulse is higher in long and thick nerves. Synaptic fatigue: The transmission of nerve impulses across the synapse stops temporarily due to the depletion of the neurotransmitter. It is required for the release of neurotransmitters from the axon terminal and excitation in the dendron of the next neuron. Synaptic delay: The impulse takes about 0.3 to 0.5 milliseconds to cross a synapse. Refractory period: It is the time interval (about a millisecond) during which a nerve fails to respond to a second stimulus even if it is strong. A neural circuit (also known as a biological neural network) is a population of neurons interconnected by synapses to carry out a specific function when activated. This occurs in the case of a subliminal or weak stimulus. All or none law: The nerve will either conduct the impulse along its entire length or will not conduct the impulse at all. Summation effect: A single subliminal stimulus will have no effect but when many such weak stimuli are given again and again they may produce an impulse due to summation of effects. The subliminal (weak) stimulus will have no effect while the supraliminal (strong) stimulus will produce the same degree of impulse as the threshold stimulus. A stimulus must have a minimum intensity called threshold stimulus, in order to be effective. This is an example of the all-or-nothing principle. If the postsynaptic cell is a neuron, a new action potential might be generated in the postsynaptic neuron and reach its postsynaptic targets. The nerve impulse (or signal) travels from a presynaptic neuron to a postsynaptic cell. Stimulus: It is any detectable, physical, chemical, electrical change in the external or internal environment which brings about excitation in a nerve/muscle/organ/organism. Ion Channels Resting Membrane and Action Potential Neuromuscular Junction / Synapses Nerve Conduction Neurotransmitters. In a resting axon (one that is not transmitting impulses), the inside of the. 1, a presynaptic neuron forms synapses with two postsynaptic neurons. List the major components of the nervous system and describe their functions. Define biological psychology, neurogenesis and explain why psychologists are interested in human biology. Conductivity: It is the ability of the nerve to transmit impulses along the whole length of the axon. Lesson 3: The Neuron And The Neural Transmission 1. Excitability/Irritability: Nerve fibres have polarized membranes, thus they have the ability to perceive stimulus and enter into a state of activity. ![]() Saveable shadowrun character sheet7/20/2023 ![]() A cheat sheet for rolling dice checks, XP, and upgrades means less flipping through the rulebook for players and the GM. Glue-bound pad of 50 ensures you have plenty for keeping track of as many new, interesting protagonists as they’d like! Double-sided, full-color character sheets make it easy to track your kitty’s abilities. These character sheets are a refill for the optional, fully-compatible accessory included in the base game for Magical Kitties Save the Day, an all-ages roleplaying game of cute, fierce kitties. Full-color art and illustration keeps the process fun! A quick-start rules guide makes it easy for players to make dice checks, determine successes, and earn XP. First, draw cards or use one of the other character-building methods outlined in the rulebook to make your kitty hero, then keep track of your stats on this two-sided character sheet. I have tried to do Cassie's original work justice and bring the sheet up to the current Sixth World rules. ![]() Reference Sheets - Shadowrun Third Edition These sheets are designed for printing out - they may appear slightly fuzzy onscreen but will look fine when. ![]() Implant Data Sheet - One page sheet with plenty of room for cyberware, bioware, cyberlinks and more. The sheet was originally started by Cassie Levett based on a Shadowrun 5e sheet and work fell to the way side as other projects came up. Remote Control Sheet - One page sheet for organizing remote control drones, from Rigger 3. ![]() " These character sheets make it easy to keep track of stats in Magical Kitties Save the Day. This is a sheet for Shadowrun Sixth World (6e). " Meow-velous full-color character tracking for Magical Kitties Save the Day. ![]() Dmca copyright infringement7/20/2023 ![]() ![]() “I hereby state that the information in this notice is accurate and, under penalty of perjury, I am the copyright owner or authorized to act on behalf of the owner of an exclusive right under the copyright law that is allegedly infringed”.”I have a good faith belief that the disputed use is not authorized by the copyright owner, its agent, or the law (e.g., fair use)”.“I hereby understand that under 17 U.S.C § 512(f) I may be liable for any damages, including costs and attorneys' fees, if I knowingly and materially misrepresent that reported material or activity is infringing”.adequate information by which we can contact you (including your name, your postal address, your telephone number, and, if available and preferably, your email address).a description of where the material that you claim is infringing is located on the Kickstarter website, in a sufficiently precise manner to allow Kickstarter to locate the material - please be as specific as possible, including the title of the work, the type of media, and any other identifying information.a description of the copyrighted work that you claim has been infringed.an electronic or physical signature of the person authorized to act on behalf of the owner of the copyright interest.In accordance with Section 512 of the DMCA, your written notice must include substantially the following information (please note that all information must be submitted in English): If you have a good faith belief that any materials accessible on or from (the “Kickstarter Platform”) infringe your copyright, you may request removal of those materials (or access to them) from the Kickstarter Platform by filing a DMCA notification ( “Take Down Notice”) by completing our. If you misrepresent that material infringes your copyright, you may be subject to liability for damages, including costs and attorneys' fees incurred by creators or other parties. Copyright laws of the United States require you to consider copyright defenses, limitations, or exceptions, such as the fair use doctrine, before sending a notice. If you're not sure whether material on Kickstarter infringes on your copyright, please consult with an attorney before filing a DMCA notification. If you are the copyright owner of content hosted on a third party site, and you have not authorized the use of your content, please contact the administrator of that website directly to have the content removed. Kickstarter does not control content hosted on third party websites, and cannot remove content from sites it does not own or control. Kickstarter also reserves the right to terminate user accounts based on a single instance of infringement. ![]() ![]() In addition to complying with the DMCA safe harbor, Kickstarter may in its sole discretion terminate user accounts of those who are repeat infringers of the intellectual property rights of others. If you’ve backed a project that was the subject of a takedown notice, you can learn what that means.If your project was the subject of a takedown notice, you can submit a counter-notification.If you believe your copyright is being infringed, you can report the alleged violation.Section 512 of the DMCA provides the rules for reporting copyright infringement and for filing a counter-notification. Kickstarter removes material that is the subject of a compliant DMCA takedown notice. Kickstarter has adopted a general policy regarding copyright in accordance with the Digital Millennium Copyright Act of 1998. ![]() ![]() The nine-piece set includes an arch, center panel, two side panels, a windowbox, and four pot rings. Installation is required and varies according to where you are hanging it.Ĭhoose from whitewash and zinc finishes to match your space. Although you will need ample outdoor wall space for it-the panels measure about 61 inches high-this elegant trellis will help create and frame an outdoor zone for entertaining. Although assembly is required (and may require two people depending on the size), once it is put together, it is freestanding and will stand up on its own once placed in a pot, planter, or even firmly in the ground.ĭimensions: 60 x 11 inches︱ Material: Steel︱ Color: Bronze or copper ︱ Shape: Obelisk︱ Weight: 9.6 pounds︱ Assembly Required: Yesįor a garden trellis that can double as wall art, the Frontgate New York Botanical Garden Alix Trellis Collection is a splurge-worthy, customizable option that you can use to hang plants, or as support for plants in separate containers on the ground below. You can even plant flowers at the bottom while having plenty of room for vines to grow tall and all around the structure. While this trellis has so many stylish touches, there is still plenty of room for your tomato plants, and other vine or climbing plants to thrive. We also appreciate its powder-coated steel finish so it will hold up to the elements. And since it's available in two finishes and six sizes, you can choose the one that fits your pot or planter and decor. The obelisk shape, floral design, and cast-iron finial at the top add interesting details. We love the Kelly Clarkson Home Kendra Steel Obelisk Trellis because it adds both charm and function to a small space. ![]() If you need more than four, you can also purchase these budget-friendly trellises in packs of six, and 12.ĭimensions: 10.7 x 6.2 x 1.1 inches (packaged)︱ Material: Plastic︱ Color: Dark green︱ Shape: Varies︱ Weight: 4.8 ounces︱ Assembly Required: Yes And since they don’t go directly into the ground, they can also be used in indoor planters. However, their compact size makes them a great choice for small patios, balconies, or decks. One trellis can support only one or two plants. Measuring 10.2 x 6.1 inches, these mini garden trellises are significantly smaller than most of our other picks. We also appreciate that the pieces connect to one another very easily, making the assembly process a breeze. Made of dark green plastic, these trellises blend in unobtrusively with any plant, garden, or yardscape. When stacked on top of one another, they are an ideal growing space for climbing plants and vines, effectively keeping them off the ground. Thanks to their versatile design, they can be arranged side by side or vertically to shape your plants as desired. Our favorite affordable option, these small, stackable trellises from Uwioff can be inserted into a pot to provide extra support for plants. The trellises are sold in packs of two or four, and they’re available in four neutral colors to match your decor.ĭimensions: 1 x 60 x 18 inches︱ Material: Metal︱ Colors: Black, butterfly-black, brown, and white︱ Shape: Rectangular︱ Weight: 14.02 pounds︱ Assembly Required: No We also appreciate that it comes fully assembled and is very easy to install-simply insert the prongs into the ground or soil. ![]() You could even arrange several trellises side-by-side to create a fence screen in your yard. We love that this unit can be placed inside a planter or used as a standalone trellis. Just note that this option is best suited for decorative blooms, and might not provide the optimal support or space for growing vegetables. ![]() And thanks to thick and sturdy iron stakes, it offers plenty of support for plants and stays put in inclement weather. The durable iron construction, combined with a rust-proof finish, will keep it looking great for years to come. Standing about 5 feet tall, this iron trellis is perfectly sized for climbing or long-stemmed plants such as roses and clematis. ![]() If you’re looking to add both height and variety to your garden, we think the Amagabeli Garden Trellis for Climbing Plants makes a stylish addition to most outdoor spaces, earning our top spot on this list. The Spruce Home Improvement Review Board. ![]() Cat quest tips7/20/2023 ![]() ![]() Solve my riddle, find my treasure, and earn my respect.” One of those mighty pillars opens the way to my treasure. “On the Tabantha Frontier, where Rayne, Piper, and Tanagar meet, ruined pillars stand together. Go through it.Įxamine the carved stone here to hear a riddle from the person who first discovered the Tunic of Awakening. After opening the chest, the wall on the left will open up. Inside here you’ll find a chest with an Ember Shirt, which raises Link’s attack in hot weather. Get off where the ground slopes down to the lava on the right, and look up to see a cave entrance (there’s a pale piece of debris in front of it which may be easier to spot. Image: Nintendo EPD/Nintendo via Polygonĭefeat the Fire Like and ride one of the platforms on the right. ![]() You can also create one with a splash fruit. Wait for or move a platform using Ultrahand/Recall so that you can cross toward the Fire Like. (Don’t touch it, obviously!) There are two ore deposits you can break on the left here.Ĭontinue following the path to the left past the broken up waterfall which has a Fire Like behind it. ![]() Then turn around and jump towards the lava waterfall. Go inside, hop over the lava directly in front of you, and open the chest for a Ruby. Image: Nintendo EPD/Nintendo via Polygonĭefeat the Horriblin at the entrance. Goronbi River Cave is located in the Eldin region, in a valley southwest of Death Mountain. We were able to avoid damage with the Flamebreaker chest piece, the Desert Voe Headband, and a heat resistant meal. Ideally you will need the Flamebreaker Armor to enter. However, be aware that this cave has extremely high levels of unbearable heat. Tell us your own Cat Quest tips in the comments below.The first thing to do is to head to Goronbi River Cave. Talk to everyone you meet and be sure to scope out the signboards in towns for extra quests. Be sure to complete as many side quests as possible to prepare your character for the more difficult main quests and earn some gold on the side. It might look like a small scale RPG, but Cat Quest is actually an open world game. Experiment with this, or even change things out based on the current enemy you're up against. However, Cat Quest gives you the opportunity to mix and match to come up with interesting combos. You can be a traditionalist if you so choose, and go for a pure mage or a pure fighter character. Instead, your character's abilities are determined by the spells you learn and the equipment you select. One of the cool things about Cat Quest is that you don't choose a traditional RPG "job", per se. As you get more familiar with each enemy, you'll be able to time these rolls a lot more carefully. Roll or dash outside of the red area to avoid taking damage. If your opponent is prepping a spell or attack, a red circle or square will appear where that attack is going to land. The most important thing to do in intense combat scenarios is pay attention to what you're enemy is doing. Off we go.Ĭombat moves quite fast in Cat Quest, and it's easy to get overwhelmed by enemies. To help you get started we have a few handy beginner's tips. You should jump on Cat Quest as soon as you're able. It's certainly a game of the year contender in our books. This game about a world populated by furry kitty warriors is actually a full-length RPG with sturdy mechanics and a lovely little story. ![]() Cat Quest is an absolutely charming open-world RPG that's taken the gaming world quite by storm. ![]() Cygwin imagemagick7/20/2023 ![]() Now we can start using and experimenting (playing) with it. Note that this tools are used only for command line calling and development APIs do not appear if you just search with ‘image’ keyword.īut if you search ‘Magick’ then only development libraries will appear. But there are several components of it and you need to install particular ones based on your purpose. This tool is similar to magick except that the original image file is overwritten (unless you change the file suffix with the -format option) with any changes you request. Fortunately there are ImageMagick libraries available on cygwin repositories which you can install. Use the magick mogrify program to resize an image, blur, crop, despeckle, dither, draw on, flip, join, re-sample, and much more. As I’m working on Windows pc and my software actually runs on Linux, I use Cygwin for development. So I decided to install ImageMagick, learn its API and use it in my software, so I can save some time. ![]() And it also may look crazy for some people if you code it from scratch when you could use already available tools, libraries. But sometimes (usually) you may find yourself when you have very limited time to finish certain project. I usually prefer to code all manipulation routines by myself so to understand the underlying logic going on there. If you only want the core library and dont care about command line utilities, you can disable dmtxread and dmtxwrite to avoid the ImageMagick dependency. Well I heard about several image manipulation tools, especially which can be used through command line particularly, but one of them caught my ear too often. This is my first post and its about how I made use of one very convenient image manipulation and image processing (^_^ yeah) tool. ![]() Editready batch process multiple files7/20/2023 ![]() Inside the batch file, the following argument replacements would be in effect before and after a shift command: Here's what I mean: Suppose I started a batch file with the command line The tool to use is the shift command, which deletes a given command-line argument and slides the remaining ones down. It's possible to write batch files to handle any number of arguments on the command line. When you have many files to process, you may get tired of typing the same batch file commands over and over, like this: Learn More Buy Processing Multiple Arguments It’s a minor inconvenience.ĮditReady is $50 as a download ( XP Under the Hood: Hardcore Windows Scripting and Command Line Power One feature missing from the software is the ability to change frame size, so you can’t output a full resolution 1080p file and use EditReady to produce a quarter resolution H.264 file. To be fair, I have observed more serious problems with Media Encoder in the past…ĮditReady can also be used to produce H.264 files, for instance as viewing copies for internet transmission. Although there was no visible difference between these files and the ones generated by EditReady, the picture data in the files were different – not wrong, just different. I used Quicktime as the reference, producing ProRes 422 files, as I reckoned that Apple software using an Apple CODEC was a sensible starting place. It’s worth noting that the results from EditReady were different to the results from the other packages, but only in a few least significant bits. EditReady was faster than the others even on a 2008 Mac Pro, which has none of the hardware acceleration of newer machines, though I presume that some of the calculations were still off-loaded to the GPU. Quicktime, Compressor and Adobe’s Media Encoder were nowhere close – EditReady isn’t just a few percent faster, in our tests it was nearly twice as fast as Media Encoder and three times as fast as Compressor (single node) and Quicktime. The UI also allows you to edit metadata – either for individual files or as a batch.Īs a simple way of converting your camera files, EditReady is an attractive package, but it sells itself on its speed – and it is really fast. ![]() There is a great deal of flexibility in the output filename, with auto-incrementing file numbers, creation date and so on, but you can also use any of the input files’ metadata in the output filename – for example camera name, reel name or shot/take information. The user interface provides (editable) presets for the encoding format and you can burn in a LUT if required. Of course, if your Mac was built before 2011, or if it’s a new Mac Pro (which uses Intel’s server chipset and so doesn’t have QuickSync) then you won’t see quite the transcoding acceleration that newer MacBooks Pros, Airs and iMacs will bring. It does this with a simple, batch interface – just drag-and-drop the files – and it does it very fast.ĮditReady leverages your Mac’s hardware to perform various bits of its transcoding – Intel’s QuickSync (built into most chip-sets since 2011) accelerates H.264 encoding and decoding, and the GPU is used to convert between colour spaces and sampling schemes, freeing the CPU to do what it’s good at, and saving power in the process. ![]() It takes pretty much any format video (if it will play in Quicktime then it’s likely to be compatible – so no REDCODE RAW) and transcodes it to ProRes, DNxHD or H.264. EditReady takes pretty much any format video (if it will play in Quicktime then it’s likely to be compatible – so no REDCODE RAW) and transcodes it to ProRes, DNxHD or H.264.Ī bit of software that promises to transcode rushes for your NLE faster than the competition sounds like a Good Thing – we all spend too much of our lives watching that little blue progress bar inch, glacially, towards its destination.ĮditReady, from Divergent Media, is just such a solution. ![]() Icd 10 insomnia with reliance on ambien7/20/2023 ![]() ![]() Sedative-hypnotics are also prescribed to patients with diseases such as generalized anxiety disorder, addiction, agitation, neurological disorders, muscle spasticity, involuntary movement disorder, alcohol withdrawal, and anxiety associated with cardiovascular or gastrointestinal conditions. The two most commonly prescribed medications to treat insomnia are benzodiazepines (BZDs) and non-benzodiazepines (non-BZDs), and other drugs such as gamma-aminobutyric acid agonists, melatonin receptor agonists, sedating antidepressants, antihistamines, and eugeroic drugs are also used but less frequently. Typical treatments for patients with insomnia include psychological therapy and the use of medications. Thus, insomnia is a major public health concern with considerable personal and socioeconomic burdens. It has been found to correlate with a number of psychological diseases such as depression and physical illnesses such as diabetes, hypertension, and cardiovascular disease. The prevalence of insomnia in Asian and Western countries ranges from 5% to 40%. Keywords: Sedative-hypnotics, Insomnia, Cancer, Cancer-free survival rate, Immune function, Viral infection Introduction The use of sedative-hypnotics should be discouraged for treating patients with or without insomnia in Taiwan. Increased risks of oral, liver, and breast cancer were found in the patients with the use of sedative-hypnotics. The cancer-free survival rate of patients who had used sedative-hypnotics was significantly lower than that of patients who had never used sedative-hypnotics.Ĭonclusions: The use of sedative-hypnotics in patients either with or without insomnia was associated with subsequent cancer development in the Taiwanese population. Regarding site-specific risk, patients with insomnia who used sedative-hypnotics had an increased risk of oral and breast cancers, and patients without insomnia who received sedative-hypnotics prescriptions had an increased risk of liver and breast cancers. Results: Patients with insomnia who used sedative-hypnotics had an adjusted hazard ratio of 1.49 compared with patients with insomnia who did not use any sedative-hypnotics, and patients without insomnia who used sedative-hypnotics had an adjusted hazard ratio of 1.68 compared with patients without insomnia who did not use any sedative-hypnotics. A Cox proportional hazards model was used to compute the 14-year cancer-free survival rates after adjustment for confounding factors. Information from the claims data, namely basic demographic details, drug prescriptions, comorbidities, and patients' survival, was extracted from the National Health Insurance Research Database for χ 2 analysis. Methods: A total of 43,585 patients were recruited, 21,330 of whom had been diagnosed with insomnia and 8,717 who had been prescribed sedative-hypnotics during this study's following period of 2002 to 2015. File import instruction Abstractīackground: The aim of this population-based 14-year historical and prospective study was to determine the relationships between the usage of sedative-hypnotics, including benzodiazepines and nonbenzodiazepines, and the risk of subsequent cancer in patients with or without insomnia among the Taiwanese population. Select the file that you have just downloaded and select import option Reference Manager (RIS). Association between Sedative-hypnotics and Subsequent Cancer in Patients with and without Insomnia: A 14-year Follow-up Study in Taiwan. E-mail address: mjchiedu.tw Moreįang HF, Lee TY, Hui KC, Yim HCH, Chi MJ, Chung MH. Mei-Ju Chi, PhD, School of Gerontology Healt h Management, College of Nursing, Taipei Medical University, No.250, Wu-Xing Street, Taipei, Taiwan, 110, R.O.C. ✉ Corresponding authors: Min-Huey Chung, RN, PhD, School of Nursing, College of Nursing, Taipei Medical University, No.250, Wu-Xing Street, Taipei, Taiwan, 110, R.O.C. *These authors contributed equally to this work. Department of Nursing, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan School of Gerontology Health Management, College of Nursing, Taipei Medical University, Taipei, Taiwanĥ. Microbiome Research Centre, St George & Sutherland Clinical School, University of New South Wales, Sydney, AustraliaĤ. School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwanģ. Department of Nursing, Taipei Medical University Hospital, Taipei, TaiwanĢ. Hui-Fen Fang 1, Tzu-Yin Lee 2*, King Cheung Hui 2*, Howard Chi Ho Yim 3, Mei-Ju Chi 4, Min-Huey Chung 2,5ġ. Research Paper Association between Sedative-hypnotics and Subsequent Cancer in Patients with and without Insomnia: A 14-year Follow-up Study in Taiwan ![]() |